ABSTRACT

A new brightening skincare regimen was developed to improve the complexion of facial skin by targeting multiple steps and pathways that affect pigmentation. The regimen consists of a facial cleanser, serum and lotion, which contain N-acetyl glucosamine* plus a variety of other benefit ingredients to collectively exfoliate pigmented areas, reduce tyrosinase activity and melanin production, and deliver an overall pigment evening effect.

DEFINITIONS

N-acetyl glucosamine is known as NeoGlucosamine^® in Exuviance products.

RESULTS

Overall improvement in skin pigmentation

• 93% of users achieved a more even skin tone after the first 4 weeks.
• 60% of subjects noticed an improvement as early as 2 weeks.
• 90% of subjects rated excellent, very good or good improvement after 16 weeks.
• Users reported more even pigmentation, less obvious brown spots, and improved clarity and radiance at the end of the 16 weeks visit.

User self-assessment on improvement during the 3 visits

Photography evidence of improvement with the use of the regimen

Visual grading and clinical photos showed

• Lighter and more even skin colour
• Brighter overall skin tone
• Reduced overall sallowness
• Lighter and less apparent brown spots
• Effects were observed in all ethnic groups

Self-assessment questionnaires confirmed that subjects noticed brighter skin tone, more even pigmentation, and less apparent brown spots

Marked improvement in pigmentation in standard lighting photographs and in cross-polarized photographs with melanin imaging applied to visualize hyperpigmented areas.