ABSTRACT

Hyperkeratinization is a primary or fundamental event in a majority of today’s skin disorders. Hyperkeratinization is usually the result of decreased desquamation due to increased corneocyte cohesion. Strength of corneocyte cohesionP is determined by strength of intercellular bonding. Intercellular bonding is weakened by water and diminished by retinoids and alpha hydroxyl acids (AHAs). Conversely, bonding is strengthened or enhanced by dehydration, vitamin A deficiency, and some alpha acetoxy acids (AAAs). Agents that control or modify keratinzation can be useful in treatment of many skin disorders.

DEFINITIONS

Corneocyte cohesion – Dead skin cells stuck to the surface of the skin

RESULTS

Removing of dead skin cells from skin surface

• AHAs aid in regulating cell renewal through the exfoliation of dead skin cells.
• AHAs do not over exfoliate the skin, causing it to be thin. It only separates the dead skin cells only when it is thick enough.

Separation of dead skin cells from skin surface after using 5% glycolic acid in hydrophilic ointment four times daily for 24 hours

Promotes regularity of skin condition in as soon as 3 weeks

• AHAs promote regularity of skin surface, improving the cosmeticity of the skin.
• AHAs are effective for skin conditions related to excessive dead skin layers on skin surface.
• Follicular hyperkeratinisation of keratosis pilaris and acneiform comedones responds well to topical AHAs. 

After application of 4 times daily of 5% glycolic aicd in hydrophilic ointment for 1 week and once daily for the next 2 weeks.